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  1. Universitätsklinik für Herzchirurgie
  2. Forschung
  3. CARE Cardiovascular Research and Engineering
  4. Publications

Publications 2024

A Novel Pumping Principle for a Total Artificial Heart. Bierewirtz T, Narayanaswamy K, Giuffrida R, Rese T, Bortis D, Zimpfer D, Kolar JW, Kertzscher U, Granegger M. IEEE Trans Biomed Eng. 2024 Feb;71(2):446-455. 

Left Atrial Decompression With the HeartMate3 in Heart Failure With Preserved Ejection Fraction: Virtual Fitting and Hemodynamic Analysis. He X, Bender M, Gross C, Narayanaswamy K, Laufer G, Jakubek S, Bonderman D, Roehrich M, Karner B, Zimpfer D, Granegger M. ASAIO J. 2024 Feb 1;70(2):107-115. 

Publications 2023

An Atraumatic Mock Loop for Realistic Hemocompatibility Assessment of Blood Pumps.  Bender M, Escher A, Messner B, Rohrich M, Fischer MB, Hametner C, Laufer G, Kertzscher U, Zimpfer D, Jakubek S, Granegger M. IEEE Trans Biomed Eng. 2023 Dec 22;PP. 

Anatomical Compliance of Cavopulmonary Assist Device Designs: A Virtual Fitting Study in Fontan Patients. Karner B, Escher A, Schorn T, Narayanaswamy K, Sachweh J, Laufer G, Hübler M, Zimpfer D, Granegger M. ASAIO J. 2023 Nov 1;69(11):1016-1024.

Left Atrial Decompression With the HeartMate3 in Heart Failure With Preserved Ejection Fraction: Virtual Fitting and Hemodynamic Analysis. He X, Bender M, Gross C, Narayanaswamy K, Laufer G, Jakubek S, Bonderman D, Roehrich M, Karner B, Zimpfer D, Granegger M. ASAIO J. 2024 Feb 1;70(2):107-115. 

In-Vitro Flow Validation of Third-Generation Ventricular Assist Devices: Feasibility and Challenges. Escher A, Thamsen B, Strauch C, Kertzscher U, Zimpfer D, Thamsen PU, Granegger M. ASAIO J. 2023 Oct 1;69(10):932-941. 

Feasibility of an Animal Model for Cavopulmonary Support With a Double-Outflow Pump.  Granegger M, Escher A, Karner B, Kainz M, Schlöglhofer T, Schwingenschlögl H, Roehrich M, Karl Podesser B, Kramer AM, Kertzscher U, Laufer G, Hübler M, Zimpfer D. ASAIO J. 2023 Jul 1;69(7):673-680.

Publications 2022

A Cavopulmonary Assist Device for Long-Term Therapy of Fontan Patients.  Escher A, Strauch C, Hubmann EJ, Hübler M, Bortis D, Thamsen B, Mueller M, Kertzscher U, Thamsen PU, Kolar JW, Zimpfer D, Granegger M. Semin Thorac Cardiovasc Surg. 2022 Spring;34(1):238-248. 

Comparison of device-based therapy options for heart failure with preserved ejection fraction: a simulation study.  Granegger M, Gross C, Siemer D, Escher A, Sandner S, Schweiger M, Laufer G, Zimpfer D. Sci Rep. 2022 Apr 6;12(1):5761. 

When Nothing Goes Right: Risk Factors and Biomarkers of Right Heart Failure after Left Ventricular Assist Device Implantation. Schlöglhofer T, Wittmann F, Paus R, Riebandt J, Schaefer AK, Angleitner P, Granegger M, Aigner P, Wiedemann D, Laufer G, Schima H, Zimpfer D. Life (Basel). 2022 Mar 20;12(3):459. 

The effect of occlusive polytetrafluoroethylene outflow graft protectors in left ventricular assist device recipients. Dimitrov K, Kaider A, Granegger M, Gross C, Angleitner P, Wiedemann D, Riebandt J, Schaefer AK, Schlöglhofer T, Laufer G, Zimpfer D. J Heart Lung Transplant. 2022 Dec;41(12):1850-1857. 

First-in-man use of the EXCOR Venous Cannula for combined cavopulmonary and systemic ventricular support in Fontan circulation failure. Karner B, Urganci E, Schlein J, Base E, Greil S, Michel-Behnke I, Granegger M, Laufer G, Zimpfer D. J Heart Lung Transplant. 2022 Oct;41(10):1533-1536. 

Hemolytic Footprint of Rotodynamic Blood Pumps.  Escher A, Gobel H, Nicolai M, Schloglhofer T, Hubmann EJ, Laufer G, Messner B, Kertzscher U, Zimpfer D, Granegger M. IEEE Trans Biomed Eng. 2022 Aug;69(8):2423-2432. 

Incidence, clinical relevance and therapeutic options for outflow graft stenosis in patients with left ventricular assist devices.  Dimitrov K, Kaider A, Angleitner P, Schlöglhofer T, Gross C, Beitzke D, Granegger M, Riebandt J, Wiedemann D, Sandner S, Schaefer AK, Schima H, Laufer G, Zimpfer D. Eur J Cardiothorac Surg. 2022 Feb 18;61(3):716-724. 

Inflow cannula position as risk factor for stroke in patients with HeartMate 3 left ventricular assist devices. Schlöglhofer T, Aigner P, Migas M, Beitzke D, Dimitrov K, Wittmann F, Riebandt J, Granegger M, Wiedemann D, Laufer G, Moscato F, Schima H, Zimpfer D. Artif Organs. 2022 Jun;46(6):1149-1157. 

Publications 2021

Strauch C, Escher A, Wulff S, Kertzscher U, Zimpfer D, Thamsen PU, Granegger M. Validation of numerically predicted shear stress-dependent dissipative losses within a rotary blood pump. ASAIO J. 2021 Oct 1;67(10):1148-1158.

Moscato F, Gross C, Maw M, Schlöglhofer T, Granegger M, Zimpfer D, Schima H. The left ventricular assist device as a patient monitoring system. Ann Cardiothorac Surg. 2021 Mar;10(2):221-232.

Dimitrov K, Kaider A, Angleitner P, Schlöglhofer T, Gross C, Beitzke D, Granegger M, Riebandt J, Wiedemann D, Sandner S, Schaefer AK, Schima H, Laufer G, Zimpfer D. Incidence, clinical relevance and therapeutic options for outflow graft stenosis in patients with left ventricular assist devices. Eur J Cardiothorac Surg. 2022 Feb 18;61(3):716-724.

Escher A, Strauch C, Hubmann EJ, Hübler PM, Bortis D, Thamsen B, Mueller M, Kertzscher U, Thamsen PPU, Kolar PJW, Zimpfer PD, Granegger M. A Cavopulmonary Assist Device for long-term Therapy of Fontan Patients. Semin Thorac Cardiovasc Surg. 2021 Jun 21:S1043-0679(21)00297-5.

Granegger M, Schlöglhofer T, Riebandt J, Schlager G, Skhirtladze-Dworschak K, Kitzmüller E, Michel-Behnke I, Laufer G, Zimpfer D. Mechanical circulatory support in pediatric patients with biventricular and univentricular hearts, JTCVS Open. Accepted for publication. 2021.

Granegger M, Küng S, Bollhalder O, Quandt D, Scheifele C, Drozdov D, Held U, Callegari A, Kretschmar O, Hübler M, Schweiger M, Knirsch W. Serial assessment of somatic and cardiovascular development in patients with single ventricle undergoing Fontan procedure. Int J Cardiol. 2021 Jan 1;322:135-141.

Publications 2020 & 2019

Boraschi A, Bozzi S, Thamsen B, Granegger M, Wiegmann L, Pappalardo F, Slepian MJ, Kurtcuoglu V, Redaelli A, De Zélicourt D, Consolo F. Thrombotic Risk of Rotor Speed Modulation Regimes of Contemporary Centrifugal Continuous-flow Left Ventricular Assist Devices. ASAIO J. 2020 Oct 15. Online ahead of print.

Mühlbacher J, Pröbstl C, Granegger M, Schiefer J, Duma A, Hüpfl M, Herkner H, Röhrich M, Schebesta K. Impact of Infant Positioning on Cardiopulmonary Resuscitation Performance During Simulated Pediatric Cardiac Arrest: A Randomized Crossover Study. Pediatr Crit Care Med. 2020 Dec;21(12):e1076-e1083.

Escher A, Choi Y, Callaghan F, Thamsen B, Kertzscher U, Schweiger M, Hübler M, Granegger M. A Valveless Pulsatile Pump for Heart Failure with Preserved Ejection Fraction: Hemo- and Fluid Dynamic Feasibility. Ann Biomed Eng. 2020 Jun;48(6):1821-1836.

Granegger M, Choi Y, Locher B, Aigner P, Hubmann EJ, Lemme F, Cesarovic N, Hübler M, Schweiger M. Comparative analysis of cardiac mechano-energetics in isolated hearts supported by pulsatile or rotary blood pumps. Sci Rep. 2019 Dec 27;9(1):20058.

Aigner P, Schweiger M, Fraser K, Choi Y, Lemme F, Cesarovic N, Kertzscher U, Schima H, Hübler M, Granegger M. Ventricular Flow Field Visualization During Mechanical Circulatory Support in the Assisted Isolated Beating Heart. Ann Biomed Eng. 2020 Feb;48(2):794-804.

Jain P, Shehab S, Muthiah K, Robson D, Granegger M, Drakos SG, Jansz P, Macdonald PS, Hayward CS. Insights Into Myocardial Oxygen Consumption, Energetics, and Efficiency Under Left Ventricular Assist Device Support Using Noninvasive Pressure-Volume Loops. Circ Heart Fail. 2019 Oct;12(10):e006191.

Granegger M, Thamsen B, Schlöglhofer T, Lach S, Escher A, Haas T, Meboldt M, Schweiger M, Hübler M, Zimpfer D. Blood trauma potential of the HeartWare Ventricular Assist Device in pediatric patients. J Thorac Cardiovasc Surg. 2019 Jul 19. pii: S0022-5223(19)31403-5.

Granegger M, Thamsen B, Hubmann EJ, Choi Y, Beck D, Valsangiacomo Buechel E, Voutat M, Schweiger M, Meboldt M, Hübler M. A long-term mechanical cavopulmonary support device for patients with Fontan circulation. Med Eng Phys. 2019 Aug;70:9-18.

Granegger M, Thamsen B, Moscato F, Schlöglhofer T, Gross C, Schneider S, Röhrich M, Kertzscher U, Zimpfer D, Affeld K, Schima H. Noninvasive assessment of blood pressure in rotary blood pump recipients using a novel ultrasonic Doppler method. Int J Artif Organs. 2019 May;42(5):226-232.

Granegger M, Valencia A, Quandt D, Dave H, Kretschmar O, Hübler M, Schweiger M. Approaches to Establish Extracardiac Total Cavopulmonary Connections in Animal Models-A Review. World J Pediatr Congenit Heart Surg. 2019 Jan;10(1):81-89.

Granegger M, Dave H, Knirsch W, Thamsen B, Schweiger M, Hübler M. A Valveless Pulsatile Pump for the Treatment of Heart Failure with Preserved Ejection Fraction: A Simulation Study. Cardiovasc Eng Technol. 2019 Mar;10(1):69-79.

Boes S, Thamsen B, Haas M, Daners MS, Meboldt M, Granegger M. Hydraulic Characterization of Implantable Rotary Blood Pumps. IEEE Trans Biomed Eng. 2019 Jun;66(6):1618-1627.

Wiegmann L, Thamsen B, de Zélicourt D, Granegger M, Boës S, Schmid Daners M, Meboldt M, Kurtcuoglu V. Fluid Dynamics in the HeartMate 3: Influence of the Artificial Pulse Feature and Residual Cardiac Pulsation. Artif Organs. 2019 Apr;43(4):363-376.

Petrou A, Granegger M, Meboldt M, Schmid Daners M. A Versatile Hybrid Mock Circulation for Hydraulic Investigations of Active and Passive Cardiovascular Implants. ASAIO J. 2019 Jul;65(5):495-502.

Publications before 2019

Granegger M, Schweiger M, Schmid Daners M, Meboldt M, Hübler M. Cavopulmonary mechanical circulatory support in Fontan patients and the need for physiologic control: A computational study with a closed-loop exercise model. Int J Artif Organs. 2018 May;41(5):261-268.

Thamsen B, Plamondon M, Granegger M, Schmid Daners M, Kaufmann R, Neels A, Meboldt M. Investigation of the Axial Gap Clearance in a Hydrodynamic-Passive Magnetically Levitated Rotary Blood Pump Using X-Ray Radiography. Artif Organs. 2018 May;42(5):510-515.

Thamsen B, Granegger M, Kertzscher U. Blood damage in ventricular assist devices. Int J Artif Organs. 2016 Jun 15;39(4):147-9.

Granegger M, Aigner P, Haberl T, Mahr S, Tamez DA, Graham J, Nunez NJ, Schima H, Moscato F. Interaction of a Transapical Miniaturized Ventricular Assist Device With the Left Ventricle: Hemodynamic Evaluation and Visualization in an Isolated Heart Setup. Artif Organs. 2016 Dec;40(12):1113-1120.

Granegger M, Schlöglhofer T, Ober H, Zimpfer D, Schima H, Moscato F. Daily life activity in patients with left ventricular assist devices. Int J Artif Organs. 2016 Jan;39(1):22-7.

Granegger M, Masetti M, Laohasurayodhin R, Schloeglhofer T, Zimpfer D, Schima H, Moscato F. Continuous Monitoring of Aortic Valve Opening in Rotary Blood Pump Patients. IEEE Trans Biomed Eng. 2016 Jun;63(6):1201-7.

Hayward C, Lim CP, Schima H, Macdonald P, Moscato F, Muthiah K, Granegger M. Pump Speed Waveform Analysis to Detect Aortic Valve Opening in Patients on Ventricular Assist Device Support. Artif Organs. 2015 Aug;39(8):704-9.

Granegger M, Mahr S, Horvat J, Aigner P, Roehrich M, Stoiber M, Plasenzotti R, Zimpfer D, Schima H, Moscato F. Investigation of hemodynamics in the assisted isolated porcine heart. Int J Artif Organs. 2013 Dec;36(12):878-86.

Granegger M, Schima H, Zimpfer D, Moscato F. Assessment of aortic valve opening during rotary blood pump support using pump signals. Artif Organs. 2014 Apr;38(4):290-7.

Moscato F, Granegger M, Edelmayer M, Zimpfer D, Schima H. Continuous monitoring of cardiac rhythms in left ventricular assist device patients. Artif Organs. 2014 Mar;38(3):191-8.

Moscato F, Wirrmann C, Granegger M, Eskandary F, Zimpfer D, Schima H. Use of continuous flow ventricular assist devices in patients with heart failure and a normal ejection fraction: a computer-simulation study. J Thorac Cardiovasc Surg. 2013 May;145(5):1352-8.

Granegger M, Moscato F, Casas F, Wieselthaler G, Schima H. Development of a pump flow estimator for rotary blood pumps to enhance monitoring of ventricular function. Artif Organs. 2012 Aug;36(8):691-9.

Moscato F, Granegger M, Naiyanetr P, Wieselthaler G, Schima H. Evaluation of left ventricular relaxation in rotary blood pump recipients using the pump flow waveform: a simulation study. Artif Organs. 2012 May;36(5):470-8.

Michalek-Sauberer A, Granegger M, Gilly H. The efficacy of spontaneous and controlled ventilation with various cricothyrotomy devices: a quantitative in vitro assessment in a model lung. J Trauma. 2011 Oct;71(4):886-92.

Granegger M, Werther T, Gilly H. Use of independent component analysis for reducing CPR artefacts in human emergency ECGs. Resuscitation. 2011 Jan;82(1):79-84.

Granegger M, Werther T, Roehrich M, Losert U, Gilly H. Human ECGs corrupted with real CPR artefacts in an animal model: generating a database to evaluate and refine algorithms for eliminating CPR artefacts. Resuscitation. 2010 Jun;81(6):730-6.